In postmortem studies, iron deposition in the cortex, particularly the temporal cortex, has been associated with the severity of beta amyloid (Aβ) and tau pathology in Alzheimer’s disease (AD), supporting an important mechanistic role for iron in AD (van Duijn et al., 2017; Bulk et al., 2018; Ayton et al., 2021). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.