Considering the regional overlap between both modalities and the evidence of QSM-tau PET associations in the temporal lobe in amnestic AD (Spotorno et al., 2020), we hypothesized that we may observe local relationships, i.e., local regional colocalization between cortical tau uptake and increased susceptibility in key atypical AD regions such as temporo-parieto-occipital regions. The gene discussed is MAPT; the disease is Alzheimer disease.