Given the crucial roles of ECM-related changes and cell adhesion in pancreatic cancer metastasis, and the pivotal role of the PI3K/AKT pathway in various physiological processes such as cell growth, proliferation, and migration, the KEGG and GO results indicated significant enrichment of DEGs in ECM and cell adhesion-related pathways with potential links to the PI3K/AKT signaling pathway. Here, AKT1 is linked to familial pancreatic carcinoma.