Several key regulators are notably upregulated in BCa cells, including METTL3, WTAP (43), fat mass and obesity-associated protein (FTO) (44), insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) (45), YTH n6-methyladenosine RNA-binding protein 1 (YTHDF1) (46), and Heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1) (47). Here, IGF2BP1 is linked to obesity due to melanocortin 4 receptor deficiency.