FH and hereditary leiomyomatosis and renal cell cancer: A review of FH-RCC cases with eosinophilic globules (Table 1) revealed: (1) no gender predilection (female: male= 4:3); (2) mean onset age of 38 years (range: 11–50); (3) frequent FH mutations (e.g., G354R, p.K80fs); (4) association with HLRCC features in some cases; (5) variable tumor sizes (0.2–21 cm) and growth patterns (solid, tubular, cystic); (6) consistent FH negativity and 2SC positivity; and (7) variable outcomes, with some patients disease-free post-surgery and others experiencing recurrence or metastasis.