This study was undertaken to measure the in vitro binding of [125I]α-Bgtx to α7 nAChR sites in AD subjects compared to cognitively normal (CN) subjects and assess potential relationships between other AD biomarkers such as Aβ plaques and Tau tangles using [18F]flotaza and [125I]IPPI, respectively (Figure 1) [20]. Here, MAPT is linked to Alzheimer disease.