EPHB1 and neoplasm: In particular, CFHR2 is functionally related to the complement regulatory protein complement factor H. CFHR2 gene mutations are associated with complement pathway abnormalities and may be associated with complement-mediated renal diseases.19) EPHB1 is an ephrin receptor that contributes to cell–cell adhesion, cell migration, and morphogenesis and is involved in developmental processes and inhibition of tumor invasion.