EPHB1 and neoplasm: WES in this case revealed mutations in several genes, including EPS15, CFHR2, EPHB1, IL15, and SMARCC2, which are involved in tumor-related processes such as cell signaling,18) immune regulation,21) chromatin remodeling, and tumor suppression.22) Notably, IL15 and CFHR2 may contribute to immune evasion within the tumor microenvironment.19,21) We also found mutations in TMEM233 and TENM1, genes not previously associated with IMT.