PRPS1 and X-linked nonsyndromic hearing loss: Variants that reduce PRS-I activity are linked to several disorders, including X-linked deafness-1 (DFNX1, MIM 304500), X-linked Charcot–Marie–Tooth neuropathy Type 5 (CMTX5, MIM 311070), and Arts syndrome (MIM 301835) [4].