RHO and epilepsy: In a mouse model of epilepsy, research found that the membrane-to-plasma ratio of Rho was significantly higher than that of the control group (Liu et al., 2018), and treatment with ROCK inhibitors contributed to the survival of neurons in the epilepsy model (Ding et al., 2010; Inan and Büyükafşar, 2008; Gisselsson et al., 2010).