To address this issue, we first searched for and collected published RCTs studying PD-1 blockade plus chemotherapy versus chemotherapy alone in treatment-naïve advanced GC, reconstructed individual patient-level data (IPD) from the previously reported KM curves of the all-randomized population and the PD-L1-high subgroup, and further derived the IPD of the PD-L1-low subgroup based on the reconstructed IPD. The gene discussed is CD274; the disease is gastric cancer.