Extensive research has elucidated the involvement of various pathways in the pathogenesis of RA, including phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) (Ba et al., 2021), janus kinase/signal transducer and activator of transcription (JAK/STAT) (Hu, Liu & Zhang, 2022), mitogen-activated protein kinase (MAPK) (Cai, Deng & Yao, 2024), Wnt/β-Catenin (Guo et al., 2023), and nuclear transcription factor-κB (NF-κB) (van Loo & Beyaert, 2011). The gene discussed is WNK2; the disease is rheumatoid arthritis.