Moreover, Cortjens B.et al revealed that Neutrophil extracellular traps cause airway obstruction during respiratory syncytial virus disease (21).Compared with the healthy people, the expression levels of GADD45a were up-regulated in RSV infected and the hospitalized RSV patients, these indicated that GADD45A may drive NET formation in RSV infected patients and leading to the disease progression. The gene discussed is GADD45A; the disease is Airway obstruction.