GDF15 and neoplasm: Univariate analysis showed that tumor number (p = 0.0001), microvascular invasion (p = 0.014), extrahepatic metastasis (p = 0.002), AST (p = 0.034), CRP (p = 0.003), BCLC stage C (p = 0.038), and serum GDF15 (p = 0.009) were significantly associated with OS (Table 2).