Parallel investigations in RA murine models (25) identify CD4+ T cells display a hypermetabolic state characterized by heightened activation of mammalian target of rapamycin complex 2(mTORC2); Notably, early-phase glycolytic inhibition substantially attenuated synovial inflammation, underscoring the therapeutic potential of metabolic modulation (25). This evidence concerns the gene CD4 and rheumatoid arthritis.