Primary composite endpointeGFR reduction Secondary outcome measureseGFR, UPC, ESKD, Fasting glucose, Hba1c, Lipids, Anti-dsDNA, C3, Memory B cells, MiR-148a, BACH1, BACH2, PAX5,Clinical relapses, Urinary tract infection, Kketoacidosis, Genital infection, Acute kidney injury. The gene discussed is BACH1; the disease is acute kidney injury.