On the other hand, in addition to miR-451a, one of the top downregulated miRNAs in EAE PM vs Ctrl PM was the anti-inflammatory miR-25-3p (98), formerly found down-regulated in Treg cells of MS patients and proposed to alter Treg cell activity in MS by targeting TGF-β biological functions (99). Here, TGFB1 is linked to myeloid sarcoma.