In RCC, multiple tumor-associated antigens have been identified for CAR-targeting, including Carboxy-Anhydrase IX (CAIX), CD70, AXL receptor tyrosine kinase (AXL), Receptor tyrosine kinase-like orphan receptor 2 (ROR2), DnaJ heat shock protein family (Hsp40) member B8 (DNAJB8), Mucin 1, C-Mesenchymal-Epithelial Transition Factor (c-Met), and Epidermal Growth Factor Receptor (EGFR). The gene discussed is CA9; the disease is neoplasm.