HIF2α promotes angiogenesis by upregulating vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF), enhances cell proliferation via cyclin D1 and glucose metabolism through glucose transporter 1, and drives tumor invasion and metastasis via stromal cell-derived factor 1 and its receptor C-X-C motif chemokine receptor 4 (150). This evidence concerns the gene EPAS1 and neoplasm.