King-Robson et al. find that despite having less healthy lifestyles, higher rates of APOE ɛ4 allele carriage and smaller brains, night/shift workers had lower levels of Alzheimer’s disease pathology as measured by amyloid PET and plasma p-tau217 at age 70 and one-third the risk of dementia by age 78. This evidence concerns the gene APOE and early-onset autosomal dominant Alzheimer disease.