PNPLA3 and Obesity: The PNPLA3 rs738409 variant has been extensively studied in normal-weight patients with MASLD.[11], [12], [13] Normal-weight carriers of the PNPLA3 rs738409 GG genotype exhibited the highest MASLD risk when compared with individuals with overweight or obesity,11 and the impact of rs738409 on MASLD prevalence was more pronounced in individuals with normal weight compared with those with overweight.14