F5 and thrombophilia: This usually occurs in women of childbearing age, most often in the setting of a peripartum or postpartum state, hypercoagulable states such as pregnancy, hormone replacement therapy, oral contraceptives, and inherited thrombophilia such as antithrombin deficiency, factor V Leiden, peripheral thrombin genetic mutation 201010, as well as hyperhomocysteinemia and uremia [4].