ESR1 and neoplasm: The pathological examination revealed tumor cells containing mucin in the intracytoplasmic, pagetoid spreading in the overlying epidermis of the primary tumor, and immunoexpression of cytokeratin 7, GATA3, and GCDFP15, and negative for hepatocyte paraffin 1 (HepPar1), α-1-fetoprotein, estrogen receptor, CD117, CDX2, all of which fit the diagnosis of invasive EMPD on the umbilical site rather than the umbilical metastasis of HCC (Figures 1b-1d).