The synchronous occurrence of both PTC and MTC in the same thyroid with a family history of medullary thyroid cancer is rare, accounting for approximately 0.2% to 1.2% of all thyroid malignancies [2,3]. Among these, cases occurring in the setting of familial or hereditary MTC, such as MEN2-associated RET mutations, are even more uncommon, with only isolated case reports and small series described in the literature. This evidence concerns the gene RET and thyroid gland disorder.