RET and thyroid gland disorder: It is distinct from other thyroid malignancies due to its neuroendocrine origin and unique biological behavior. Sporadic MTC constitutes 75% to 80% of cases, with hereditary MTC making up the remaining 20% to 25%, and it is associated with an autosomal dominant germline mutation in the rearranged during transfection (RET) proto-oncogene and often manifests as part of multiple endocrine neoplasia type 2 (MEN 2).