MMP9 and breast neoplasm: Importantly, owing to the intrinsic bimodal photothermal and photoacoustic imaging abilities, FCP NPs effectively guided and monitored the in vivo treatment process, which facilitated to restrict the growth of both primary and metastatic breast tumor in vivo due to coordinated PTT and anti-inflammation as confirmed by TUNEL, ki67, and matrix metalloproteinase-9 stainings.