Disease-causing variants in the SLC12A3 associated with Gitelman syndrome had the highest contribution of a single gene to the overall calculated lifetime risk of ARKDs in the European gnomAD with 2.28 (1.88–2.74; European gnomAD), and based on the whole gnomAD dataset the second largest contribution with 1.48 (1.23–1.78; worldwide gnomAD) per 100,000, respectively. This evidence concerns the gene SLC12A3 and Gitelman syndrome.