ALB and diabetes mellitus: A recent RCT found that, semaglutide 2.4 mg/wk in 101 adults with CKD without diabetes led to a mean weight loss 10.2 kg and a 48.6% reduction in urinary albumin-to-creatinine ratio over 24 weeks, compared with a 1.2 kg weight loss and 7.4% increase in urinary albumin-to-creatinine ratio in the placebo group.36