Midlife obesity also increased p‐tau181 in CA1 (41%, p = 0.05, Figure 1S‐,T) with no changes in expression of the hMAPT transgene (Figure S1Q), nor tau phosphorylating enzymes p‐PKA, GSK3β, or CDK5 in cortex or hippocampus (Figure S1R–Y). This evidence concerns the gene GSK3B and obesity disorder.