Furthermore, in 3xTg‐AD, ethanol had no effect on levels of cortical presenilin 1 (PSEN1) or BACE1 protein (Figure S1E,F) and had minimal impacts on the major tau‐phosphorylating kinases (pSer9‐GSK3β, pTyr216‐GSK3β, p‐PKA) and the tau phosphatase PP2A (Figure S1G–K). This evidence concerns the gene BACE1 and Alzheimer disease.