The 3xTg‐AD mouse model (APPSwe, tauP301, Psen1tm1Mpm) was used since it shows a progressive age‐related increase in pathologic Aβ and tau species, seen first in entorhinal and hippocampal regions, followed by cortex at later ages, similar to LOAD.21, 56. Here, MAPT is linked to Alzheimer disease.