CDK5 and obesity due to melanocortin 4 receptor deficiency: Midlife obesity also increased p‐tau181 in CA1 (41%, p = 0.05, Figure 1S‐,T) with no changes in expression of the hMAPT transgene (Figure S1Q), nor tau phosphorylating enzymes p‐PKA, GSK3β, or CDK5 in cortex or hippocampus (Figure S1R–Y).