Midlife obesity also increased p‐tau181 in CA1 (41%, p = 0.05, Figure 1S‐,T) with no changes in expression of the hMAPT transgene (Figure S1Q), nor tau phosphorylating enzymes p‐PKA, GSK3β, or CDK5 in cortex or hippocampus (Figure S1R–Y). Here, MAPT is linked to obesity due to melanocortin 4 receptor deficiency.