Furthermore, in 3xTg‐AD, ethanol had no effect on levels of cortical presenilin 1 (PSEN1) or BACE1 protein (Figure S1E,F) and had minimal impacts on the major tau‐phosphorylating kinases (pSer9‐GSK3β, pTyr216‐GSK3β, p‐PKA) and the tau phosphatase PP2A (Figure S1G–K). Here, PSEN1 is linked to Alzheimer disease.