Expression of PLIN4, which can prevent lysosomal degradation of cytosolic lipid droplets,66 was increased with age in WT mice and by both ethanol and obesity in 3xTg‐AD mice, whereas PLIN2 and PLIN3, which promote lysosomal degradation,67 were reduced. Here, PLIN2 is linked to obesity due to melanocortin 4 receptor deficiency.