CD8A and neoplasm: By integrating RNA‐seq, immunohistochemistry (IHC) and immunofluorescence (IF) data, the study demonstrated that L19–IL2 treatment spatially orchestrates a robust influx of cytotoxic CD8+ T cells and NK cells into the tumour core, effectively converting a ‘cold’ TME into a ‘hot’ one and potentially mitigating resistance to conventional cancer therapies.