Furthermore, by incorporating pan‐cancer analyses using TCGA bulk RNA‐seq, pan‐cancer protein data, pan‐cancer cell line expression data, pan‐cancer scRNA‐seq data and public spatial transcriptomics data of ovarian cancer (OC; 10X official data), BRCA (10X official data), PAAD128 and HNSC,129 the authors demonstrated that THBS2+ CAFs promote EMT and drive oxaliplatin resistance via COL8A1‐mediated activation of the PI3K–AKT pathway. This evidence concerns the gene AKT1 and cancer.