CEP55 is a key protein in cytokinesis50, whose overexpression is associated with genomic instability, one of the hallmarks of cancer.51CEP55 overexpression promotes genomic instability by51, activates PI3k/Akt pathway signaling52 and inhibition of apoptosis.53 However, no previous studies have investigated its role in cuproptosis. Here, CEP55 is linked to cancer.