Taking such an approach, we previously found a proteomic signature with the Olink proximity extension assay that predicted cognitive decline in MCI A+ and which was associated with immune system processes, signal transduction and neuronal death.8 However, in that study, it remained unclear to what extent the processes related to cognitive decline in MCI A+ may depend on tau status, as the sample size was too small for such stratified analyses. Here, MAPT is linked to Mental deterioration.