Last, we compared our results to those described in our previous study using the Olink platform.8 In the present study, we measured 76 of the proteins found to be predictive of progression to dementia, and found that the majority of these (52% in A+T+ to 68% in A+T−) had the same direction of effect sizes, including Cathepsin S (CTSS), TEK receptor tyrosine kinase (TEK) and Cluster of differentiation 46 (CD46). This evidence concerns the gene CD46 and dementia.