MAPT and Alzheimer disease: According to the recently revised National Institute on Aging-Alzheimer's Association (NIA-AA) criteria, an A+T– profile fulfils the biological definition for AD and are at increased risk of progression of clinical symptoms.21 This is in line with the present study where we observed that individuals with MCI and an abnormal amyloid status and abnormal tau are at increased risk of developing dementia and had a steeper decline than MCI with abnormal amyloid and normal tau.