This analysis revealed a persistent positive association of ARA positivity with dcSSc (OR: 2.18 [1.85–2.56]), joint manifestations (OR: 1.36 [1.03–1.80]), GAVE (OR: 2.70 [1.52–4.81]), SRC (OR: 7.93 [5.74–10.95]), Raynaud’s phenomenon (OR: 1.02 [1.01–1.03]), ILD (OR: 1.12 [1.02–1.23]) and cancer (OR: 1.86 [1.33–2.59]). This evidence concerns the gene SRC and interstitial lung disease.