TERT and cancer: To further investigate whether other cancer models display the hypermethylation signatures we identified in patients, we revisited a classic model initially reported by Weinberg and colleagues in 1999, which introduces human telomerase catalytic subunit (hTERT), the simian virus 40 large T antigen (SV40), and the H-Ras oncoprotein (H-RASV12) into BJ fibroblasts [38].