The main factor associated with T-ALL hypermethylation appears to be the tumor type, as mice that develop acute myeloid leukemia (LAML) do not show substantial patient-like CGI methylation even when using the same genetic drivers (e.g. loss of DNMT3A, Fig. 6a and b, Additional file 2: Fig. S7a). This evidence concerns the gene DNMT3A and acute lymphoblastic leukemia.