KRAS and colon adenoma: We generated reduced representation bisulfite sequencing (RRBS) data sets for two commonly used colon adenoma/carcinoma models (ApcMin/+ and Apcfl/+ combined with different Kras mutations (KrasG12D/+, KrasG13D/+ or KrasA146T/+)) [40–42] as well as target enrichment methylation data sets for a pancreatic adenocarcinoma model (driven by KrasG12D/+) that can be further accelerated by genetic obesity (KCO model) [43].