TLR4 and myocardial infarction: Post-myocardial infarction, exosomal miR-146a from transfected ADSCs directly suppressed early growth response factor 1 (EGR1) activation and IL-1β/-6 and TNF-α expression due to inhibition of the toll-like receptor 4 (TLR4)/NF-κB pathway [53].