In a unilateral ureteral obstruction (UUO) model, an antagomir targeting let-7i-5p reduced renal fibrosis by limiting collagen and fibronectin secretion of cells undergoing epithelial-mesenchymal transition (EMT) via inhibition of tuberous sclerosis complex 1 (TSC1) and mammalian target of rapamycin (mTOR) pathways [38]. Here, TSC1 is linked to renal fibrosis.