In multivariate analysis, PDGFRβ was the only independent predictor of significant liver fibrosis (≥ F2) in diabetic MAFLD patients (p = 0.006) [OR (LL – UL 95% C.I) = 12.574 (2.065–76.558)] as well as in nondiabetic MAFLD patients (p = 0.001) [OR (LL – UL 95% C.I) = 3.313 (1.911–5.743)]. The gene discussed is PDGFRB; the disease is Hepatic fibrosis.