PDK1 and neoplasm: Overexpression of PDK1 accelerates tumor growth in several malignancies, with continuing activation of the PI3 K/PDK1/AKT pathway (Tao et al. 2024; Glaviano et al. 2023; Agrawal et al. 2025; Hao et al. 2025; Watt and Goel 2022; Ippen et al. 2019).