LIMA1 and head and neck squamous cell carcinoma: Association between low LIMA1 mRNA expression and better HNSCC patient overall survival was also confirmed independently from the TCGA dataset (HNSCC cohort 2), in which the prognostic effect of low LIMA remained highly significant in the multivariable model controlling for age, gender, T class, and nodal status (HR 0.53; 95% CI: 0.40–0.69, P < 0.001, Fig. EV2A).