LIMA1 silencing from a PDX derived from HNSCC#16 tumor with high LIMA1-alpha expression (Appendix Fig. S5A; Fig. 4D) did not impact tumor size (Fig. 4E), while the number of invading cells in the zebrafish embryo xenograft model was statistically significantly decreased (Fig. 4F). Here, LIMA1 is linked to head and neck squamous cell carcinoma.