In this regard, Parkinson’s Disease is commonly associated with endolysosomal trafficking phenotypes, while CHMP2B and CHMP1B, whose homologues both play roles in Rab11-exosome and DCG biogenesis in fly SCs (Marie et al, 2023), are linked to frontotemporal dementia and hereditary spastic paraplegia respectively (Goedert et al, 2012; Reid et al, 2005). This evidence concerns the gene CHMP2B and hereditary spastic paraplegia.