KDM4A and neoplasm: Furthermore, overexpression of JMJD2A leads to a decrease in H3K36 methylation, reducing HR repair efficiency, which may weaken the radiation resistance of tumors.448,449 On the other hand, Metnase, a methyltransferase for H3K36, can promote NHEJ repair, thereby enhancing the radiation resistance of tumor cells.450 In addition, the dynamics of H3K27me3 are also related to radiotherapy sensitivity.