The MBD proteins family stands out as primary contenders for deciphering DNA methylation, as they can recruit chromatin remodelers, HDACs, and methylases to methylated DNA, which participates in gene repression.189 The MBD protein family includes multiple members, such as MBD2 and MBD3, which affect gene expression by regulating DNA methylation and histone modifications to, thereby participating in the formation and progression of tumors.190 MBD2 exhibits significant differences in expression levels and functions across different types of cancer (Fig. 3). This evidence concerns the gene MBD2 and cancer.