CGAS and neoplasm: NSUN2, known as an eraser of m5C, can suppress the cGAS/STING signaling pathway when overexpressed, thereby reducing the immunotherapy resistance of tumors.634 NSUN2 methylates ICAM-1 mRNA and promotes its translation, inhibiting the polarization of M2-type macrophages, which in turn reduces tumor metastasis and enhances the effectiveness of immunotherapy.