In ovarian cancer patients, YBX1 modulates the expression of multiple downstream targets, including AKT, thereby promoting tumor proliferation and enhancing resistance to paclitaxel.302 Compared to non-resistant HCC cases, YBX1 expression is increased in chemotherapy-resistant HCC, indicating that YBX1 plays a key role in the observed chemoresistance in HCC.552 The m7G modification affects chemoresistance by regulating DNA damage repair, cancer migration, and invasion309,321,553,554 (Fig. 5). This evidence concerns the gene YBX1 and ovarian cancer.