PNMA2 and cancer: Notably, FTO inhibitors are highly effective against cancer.794,795 Moreover, since the elucidation of the crystal structure of FTO in 2010, a range of inhibitors targeting its substrate binding sites has been developed, including anthraquinone, entacapone, meclofenamic acid (MA), MA2, as well as FB23 and FB23-2.795,796 The selectivity for FTO and cell membrane permeability improved with each generation.797,798 In preclinical investigations, FTO has demonstrated efficacy when used in conjunction with cancer therapeutic agents.