The dual function of ALKBH5 in modulating tumor growth is evident in colon cancer, lung cancer, renal cell carcinoma, and osteosarcoma, highlighting the complex nature of each m6A regulator in disease onset and progression.203,226 ALKBH5 exhibits high expression levels in hepatocellular carcinoma (HCC), gastric cancer and breast cancer (Fig. 3). Here, ALKBH5 is linked to osteosarcoma.