ALKBH5 and AL amyloidosis: Additionally, ALKBH5 contributes to poor survival rates in glioblastoma multiforme (GBM) by regulating ADAM19 and the transcription factor FOXM1.227,228 Besides, in bladder cancer, osteosarcoma, and multiple myeloma, the expression of ALKBH5 is also upregulated, primarily promoting the development and progression of tumors by affecting m6A modification.229–231 Oppositely, ALKBH5 is downregulated in prostate cancer and is pivotal in regulating the Wnt signaling pathway.