Interestingly, when YTHDF2 is upregulated in esophageal and gastric cancers, it suppresses neoplastic cell proliferation and triggers programmed cell death, indicating a protective role against these malignancies.246,247 These findings highlight the dual nature of YTHDF2 in cancer, where its role as a promoter or suppressor of cancer progression is profoundly contingent upon the specific tumor subtype and cellular milieu. The gene discussed is YTHDF2; the disease is cancer.