EGFR and neoplasm: For example, lnc-EGFR aids liver cancer cell growth by promoting Treg cell differentiation and suppressing CTL activity, facilitating immune escape.642 In breast cancer, increased lncRNA SNHG1 in CD4+ T cells boosts IDO expression by binding to miR-448, promoting Treg cell maturation and immune evasion.643 During the process of tumor immune escape, cytotoxic T lymphocytes (CTLs) may become dysfunctional or exhausted,644 and lncRNAs play a significant regulatory role in this process.