KAT8 and breast carcinoma: In contrast, overexpression of KAT2A, KAT2B, KAT4, and MOF is a characteristic feature of malignant kidney tumors.96,97 In contrast, KAT2B is downregulated in gastric cancer cells and appears to be positively correlated with the CDKN1A tumor suppressor mRNA levels.98 In addition, upregulation of lysine acetyltransferase 7 (KAT7) was observed in multiple breast cancer cell lines, which was found to enhance the PI3K/AKT signaling pathway and confer radioresistance by activating the transcription of PIK3CA99 (Fig. 3).