CCND2 and acute myeloid leukemia: Take miR-328-3p as an example, the upregulation of MALAT1 led to its downregulation in AML cells, resulting in the overexpression of Cyclin D2 (CCND2), which elevates the fraction of cells arrested in the G1 phase and diminishes the responsiveness of HL-60/A to Ara-C.761,762 It is essential to acknowledge that histone variants could also impact expression of lncRNA.