DNMT3B and cancer: I In a mouse model with a knockout of the Dnmt3b gene, the absence of DNMT3B accelerates the development of lymphoma, indicating that DNMT3B may act as a tumor suppressor gene in normal cells, inhibiting tumor development by stabilizing DNA methylation patterns.180 It is worth highlighting that the abnormal expression of DNMT3B varies among different types of cancer, which implies that both its overexpression and silencing can exert an impact on gene expression.