ALKBH1 and familial pancreatic carcinoma: Recent research has highlighted that ALKBH1 is not only overexpressed in CRC but also plays a pivotal role in cancer metastasis.261 Besides, ALKBH1 typically acts as an oncogene, promoting tumorigenesis, as evidenced in glioma and gastric cancer.261 Furthermore, in lung cancer, the upregulation of ALKBH1 in both tissue and cellular contexts has been shown to enhance cell invasion and migration.262 However, in the context of pancreatic cancer, low levels of ALKBH1 expression are associated with a particularly poor prognosis263 (Fig. 3).