EIF4A3 and chronic myelogenous leukemia, BCR-ABL1 positive: For instance, circ_SIRT1 binds to EIF4A3, upregulating ATG12, which enhances autophagy and imatinib resistance in chronic myeloid leukemia (CML).717 Reports suggest that certain circRNAs can trigger signaling pathways causing resistance to targeted therapies.