EP300 and central nervous system cancer: Specifically, general control of general nucleotide synthesis 5 (GCN5), which is one type of KATs, activation of this was detected in human glioma, colon cancer, breast cancer and lung carcinoma.93–95 Conversely, in solid tumors including ovarian, gastric, and esophageal cancer, the p300-CBP-associated factor (pCAF) is commonly diminished.83 Additionally, the aberrant expressions of KAT4, KAT5, MYST1, MYST3, MYST4, KAT2A, KAT2B, and p300 has been noted in colorectal cancer (CRC) as well.