M5C-related enzymes are frequently dysregulated in tumors, and the NSUN family proteins, which consists of NSUN1-7, plays a significant role in this context.275 Recent investigations have demonstrated that NSUN3 expression is significantly elevated in individuals diagnosed with low-grade glioma and head and neck squamous cell carcinoma (HNSCC). Here, NSUN3 is linked to head and neck squamous cell carcinoma.