WIF1 and pachyonychia congenita: It achieves this by decreasing the RNA methylation of Wnt inhibitory factor 1 (WIF-1), thereby inhibiting the tumorigenesis of PC.232,233 Moreover, reduced levels of ALKBH5 are correlated with an unfavorable prognosis in PDAC.234 In summary, ALKBH5 plays a multifaceted role in cancer, with its expression levels and impact on tumorigenesis varying across different cancer types.