AKT1 and breast cancer: For instance, in gliomas, miRNA-7 exerts an inhibitory effect on IRS-1 and IRS-2, which are pivotal regulators within the IGF-1R/Akt pathway.707 In breast cancer, miRNA-205 could enhance tamoxifen resistance and proliferation by targeting E2F1.708 In CRC, miR-100 and miR-125b together activate the Wnt/β-catenin pathway, boosting resistance to cetuximab.709 Moreover, miRNAs have a bearing on receptor regulation and the sensitivity to therapy.