Similarly, circ-BGN can promote resistance to trastuzumab in breast cancer by enhancing OTUB1-mediated SLC7A11 deubiquitylation and alleviating ferroptosis.722 CircRNAs are of pivotal significance in modulating the sensitivity and resistance to cancer treatment, thus presenting novel therapeutic strategies and potential biomarkers for further exploration in the field of oncology. This evidence concerns the gene OTUB1 and cancer.