FOXM1 and cancer: Domatinostat (a histone deacetylase inhibitors (HDACi)) have been shown to sensitize pancreatic cancer to gemcitabine/taxol by targeting the cancer stem cell compartment through the modulation of FOXM1.519 Additionally, inhibitors of HDAC11 are found to attenuate the self-renewal capacity of lung adenocarcinoma stem cells and overcome resistance to chemotherapy agents by downregulating Sox2, thereby offering novel pathways for enhancing the efficacy of cancer treatments520 (Fig. 5).