Additionally, a piRNA-like small RNA, piRNA-Ls, has been shown to induce chemoresistance to DDP-based therapy by suppressing apoptosis in lung squamous cell carcinoma.600 A recent study found that piR-FTH1 is frequently downregulated in six human cancer cell lines, with high Fth1 expression linked to doxorubicin resistance. This evidence concerns the gene FTH1 and cancer.