POLI and cancer: In HCC, miR-2117 is found to be downregulated, and this downregulation serves to facilitate the self-renewal of liver tumor stem cells as well as tumorigenesis, ultimately culminating in cisplatin resistance.585 In NSCLC, miR-3163 targets the EXO1/Polη/Polι axis, inhibiting the growth of cancer stem-like cells in NSCLC and inducing apoptosis, thereby increasing the resistance of these cells to cisplatin.586 In NSCLC, miR-3163 targets the EXO1/Polη/Polι axis, inhibiting cancer stem-like cell growth and inducing apoptosis, which increases resistance to cisplatin.