CBX3 and breast cancer: For example, lncRNA TYMSOS promotes the growth and metastasis of breast cancer cells and leads to immune escape through the CBX3/ULBP3 or SYVN1/ULBP3 axis.647 Furthermore, lncRNAs partake in the formation of resistance to immunotherapy by modulating diverse molecular pathways within tumor cells, including those related to cell cycle regulation, apoptosis, metabolism, and epigenetic modifications.