LncRNA LINC01956 undergoes dynamic structural remodeling that enhances the recruitment of O6-methylguanine DNA methyltransferase (MGMT) mRNA expression, which promotes DNA damage repair and tumor proliferation.578 LncRNAs can not only be regarded as potential biomarkers for the early diagnosis of cancer patients, but their expression profiles may also assist in predicting the sensitivity of cancer cells to different chemotherapy drugs, thereby alleviating chemoresistance (Fig. 5). Here, MGMT is linked to cancer.