Expression of FTO is reduced in melanoma.222 And upregulation of FTO overexpression inhibits CSC proliferation and tumorigenic potential in vitro cultures and in vivo xenograft murine models.223–225 Besides, in ovarian cancer, FTO is downregulated and promotes tumorigenesis and self-renewal by affecting the m6A modification levels of specific genes.223 The role of FTO may vary in different tumors, and additional investigations are required to delineate its specific mechanisms of action in tumor development. The gene discussed is FTO; the disease is melanoma.