The overexpressed NSUN2 interacts with YBX1, promoting the translation of quiescin sulfhydryl oxidase 1 (QSOX1) mRNA, thereby enhancing the resistance of non-small-cell lung cancer to gefitinib.697 M7G also shows relevant effects in the resistance to targeted therapy. This evidence concerns the gene QSOX1 and non-small cell lung carcinoma.