Domatinostat (a histone deacetylase inhibitors (HDACi)) have been shown to sensitize pancreatic cancer to gemcitabine/taxol by targeting the cancer stem cell compartment through the modulation of FOXM1.519 Additionally, inhibitors of HDAC11 are found to attenuate the self-renewal capacity of lung adenocarcinoma stem cells and overcome resistance to chemotherapy agents by downregulating Sox2, thereby offering novel pathways for enhancing the efficacy of cancer treatments520 (Fig. 5). Here, SOX2 is linked to cancer.