The upregulation of FOXM1 induced by IR is mitigated by ALKBH5 inhibition, suggesting an alternative pathway through which ALKBH5 may mediate radioresistance in GBM.474–476 In addition, the m6A demethylase FTO has been implicated in the development of radioresistance. This evidence concerns the gene ALKBH5 and glioblastoma.