Recent research indicates that RNA modifications exert a crucial influence on modulating resistance to targeted therapies by influencing cellular processes such as apoptosis, proliferation, tumor migration, and invasion.690 Recent researches have shown METTL14 reduces the expression of HNF3γ mRNA through m6A modification, with HNF3γ being a key regulator of sorafenib resistance. The gene discussed is FOXA3; the disease is neoplasm.