Notably, FTO inhibitors are highly effective against cancer.794,795 Moreover, since the elucidation of the crystal structure of FTO in 2010, a range of inhibitors targeting its substrate binding sites has been developed, including anthraquinone, entacapone, meclofenamic acid (MA), MA2, as well as FB23 and FB23-2.795,796 The selectivity for FTO and cell membrane permeability improved with each generation.797,798 In preclinical investigations, FTO has demonstrated efficacy when used in conjunction with cancer therapeutic agents. Here, FTO is linked to cancer.