ALKBH5 and glioblastoma: ALKBH5 is essential for sustaining leukemia stem cell characteristics, and mediates mRNA stability of receptor tyrosine kinase AXL by m6A modification (KDM4C-ALKBH5-AXL signaling axis).753 In glioblastoma with TMZ resistance, TMZ can induce a SOX4-dependent augmentation in chromatin openness at the region of METTL3 through enhancement of H3K27ac levels and the recruitment of RNA polymerase II.