CD274 and gastric cancer: As for gastric cancer, circ_0136666 upregulates PRKDC by sponging miR-375-3p, which activates the PD-L1 phosphorylation pathway, preventing PD-L1 degradation and aiding immune evasion.654 In esophageal cancer, circ-VIM promotes immune evasion by increasing PD-L1 expression through miR-124 sponging.655 Similarly, in gastric cancer, hsa_circ_0001479 boosts DEK expression by sponging miR-133a-5p.