For instance, the lncRNA HOTAIR interacts with the PRC2 and the LSD1/CoREST/REST complex, facilitating the coordinated regulation of histone H3K27 methylation and H3K4 demethylation.764 It is reported that HOTAIR mediated the switching of histone H3 lysine 27 acetylation to methylation to promote EMT in gastric cancer.765 lncRNAs can guide histone modification enzymes to specific genomic loci, thereby influencing the local chromatin state and gene expression. The gene discussed is HOTAIR; the disease is gastric cancer.