MBD2 and esophageal cancer: For example, H3K27me3 has been accessed as a prognostic indicator in patients with prostate, breast, ovarian, pancreatic and esophageal cancer.109 High levels of H3K27me3 correlate with poor prognosis in esophageal cancers.110 The variations in histone methylation levels, orchestrated by HMTs and demethylases, are frequently altered in tumors.