This, in turn, activates the Wnt/β-catenin pathway, which not only promotes cell growth but also reduces the infiltration of CD8+ T cells, thus facilitating immune evasion.656 In ovarian cancer, circ-NFIX promotes tumor progression and immune evasion by sponging miR-647 and activating IL-6R/JAK1/STAT3 signaling.657 CircRNAs can also influence immune cell function in the tumor microenvironment. The gene discussed is CD8A; the disease is neoplasm.