Circ_SPECC1 functions as a sponge to attach miR-526b and therefore regulates its target genes, including lysine demethylase 4A (KDM4A) and the downstream signaling target YAP1/KDM4A, and suppressing the invasion and growth of gastric cancer cells.769 In human bladder cancer, circXRN2, which is aberrantly downregulated in bladder cancer tissues and cell lines, suppresses tumor progression driven by H3K18 lactylation by activating the Hippo signaling pathway.770. This evidence concerns the gene KDM4A and neoplasm.