CD276 and pancreatic neuroendocrine neoplasm: Specifically, the piRNA piR-hsa-30937, found in small extracellular vesicles from pancreatic neuroendocrine neoplasms, can be released into the microenvironment and enhance CD276 expression in macrophages via the PTEN/AKT pathway, leading CD276+ TAMs to inhibit T-cell antitumor immunity663 (Fig. 6).