In lung adenocarcinoma, lncRNA MALAT1 acts as a ceRNA, suppressing the expression of miR-125 and promoting the expression of Rab25, leading to resistance to EGFR-TKI (erlotinib) in lung adenocarcinoma.706 LncRNAs, like UCA1, can be secreted through exosomes, contributing to drug resistance in recipient cells (Fig. 7). This evidence concerns the gene RAB25 and lung adenocarcinoma.