In lung adenocarcinoma, lncRNA MALAT1 acts as a ceRNA, suppressing the expression of miR-125 and promoting the expression of Rab25, leading to resistance to EGFR-TKI (erlotinib) in lung adenocarcinoma.706 LncRNAs, like UCA1, can be secreted through exosomes, contributing to drug resistance in recipient cells (Fig. 7). The gene discussed is EGFR; the disease is lung adenocarcinoma.