Current research indicates that TRMT6/61A is upregulated in bladder cancer and is associated with an increase in m1A modification levels.256 Additionally, TRMT6/61A has been found to enhance the proliferation of gastrointestinal and breast cancer cells, exerting an oncogenic effect.257–260 TRMT6 exhibits an upregulated trend in certain types of cancer, particularly bladder cancer, and is associated with the degree of malignancy and the unfolded protein response. The gene discussed is TRMT6; the disease is urinary bladder cancer.