H2AX and pharyngeal squamous cell carcinoma: Notably, overexpressed METTL3 interacts with SOX2 transcripts, stabilizing them and thereby contributing to heightened DNA damage repair capabilities, which in turn bolsters the resistance of glioma stem-like cells to γ-irradiation.468 Additionally, METTL3-mediated m6A modification of mRNA impedes the degradation of H2A histone family member X (H2AX) mRNA, leading to increased H2AX expression and facilitating both DNA damage repair and cell survival, and then promote radiation resistance.469 In pharyngeal squamous cell carcinoma, METTL3 has been identified as a key inducer of radioresistance.