USP22 and neoplasm: Besides, RNF20 and RNF40 have been observed to be downregulated in seminoma, basal-like breast cancer, and colorectal cancer.135–137 And USP22 was found to overexpressed in prostate cancer.138 These investigations reveal that enzymes associated with histone ubiquitination are aberrantly regulated across diverse tumor types and exhibit a strong correlation with tumor proliferation, advancement, and metastatic dissemination.