There was a study indicated that LINC-RA1 maintained the stability of H2B K120 monoubiquitination (H2BK120ub1) by interacting with H2B and suppressing the engagement between H2Bub1 and ubiquitin-specific protease 44 (USP44), thereby suppressing autophagy and consequently fostering radioresistance in glioma.491 Another crucial function of lncRNAs is to act as a sponge for miRNAs, exerting pivotal functions in radioresistance through the modulation of genes or proteins at both the transcriptional and post-translational levels. Here, USP44 is linked to central nervous system cancer.