LncRNA SP100-AS1 induces radioresistance in CRC through sponging miR-622 and enhancing the stability of ATG3.492 LncRNA FGD5-AS1 promotes the radiotherapy resistance in breast cancer cells by upregulating MACC1 expression through competitive binding with miR-497-5p.493 Besides, lncRNA also induce radioresistance via activating multiple signaling pathway, including PI3K/AKT/mTOR494 Wnt /β-Catenin495 YAP1/AKT.496. The gene discussed is AKT1; the disease is breast carcinoma.