In NSCLC, upregulated circ-0086720 inhibits cell survival and reduces apoptosis, thereby increasing its radiotherapy resistance.508 In CRC, circ-ZNF609 promotes advancement and radioresistance of prostatic carcinoma cells by accelerating the glycolytic action of the miR-501-3p/HK2 axis.509 In CRC, the upregulation of circ-0055625 promotes cell migration, proliferation, migration, and further induces radiotherapy resistance in CRC.510 CircRNAs also induce radiotherapy resistance by binding to related molecules. The gene discussed is ZNF609; the disease is colorectal carcinoma.