XIST and non-small cell lung carcinoma: LncRNAs alter the radiosensitivity of cancer cells by regulating radiation-related pathways, including DNA damage repair, cell cycle, cancer stem cell phenotype, and apoptosis.485 For example, the downregulation of the lncRNA XIST expression inhibits the viability and survival of NSCLC cells, facilitates apoptosis, and enhances sensitivity to ionizing radiation.