PRMT5 methylates various substrates including p53 and histones,47 and participates in DNA repair, cell cycle regulation, and transcriptional control.48–50 PRMT5, as an epigenetic enforcer, upregulated c-Myc expression in gastric cancer, synergistically promotes cancer cell proliferation and inhibits apoptosis.51 This evidence concerns the gene TP53 and gastric cancer.