We once reported that the lung epithelial cell TLR3 can sense circulating tumor exosomal RNA, leading to lung chemokine production, inflammatory neutrophil recruitment and pro-metastatic niche formation to promote cancer lung metastasis.23 Aberrant TLR3 activation may induce proinflammatory cytokines and tumor immunosuppression. The gene discussed is TLR3; the disease is cancer.