TLR3 and cancer: To investigate the role of nuclear TLR3 of cancer cells, we rescued TLR3 knockout Panc1 cells by expressing wild-type TLR3, the TLR3 with a nuclear localization signal (NLS-TLR3), or the TLR3 with a nuclear export signal (NES-TLR3) (Supplementary Fig. 5a–f).