Besides, c-Myc inhibitor and PRMT5 inhibitor both suppressed the metastasis induced by TLR3 rescue in the pancreatic cancer liver metastasis model bearing TLR3 knockout cancer cells, reinforcing the non-redundant role of c-Myc/PRMT5 as downstream effectors. The gene discussed is TLR3; the disease is familial pancreatic carcinoma.