Nuclear translocated TLR3 may be linked to the recognition of dsRNA aggregated in cancer cell nucleus upon chemotherapeutic stress and bridges TLR3/PRMT5/c-Myc interaction to trigger symmetric dimethylation and multimerization of c-Myc, and the molecular events contribute to cancer metastasis and chemoresistance (Fig. 6j). The gene discussed is TLR3; the disease is cancer.