On the other hand, TLR3 shows significant upregulation, within both neoplastic and stromal compartments across various malignancies including breast, lung or esophageal cancers, in which it regulates cancer cell proliferation, invasion and apoptosis.52,53 Interestingly, our investigations revealed a novel nuclear localization pattern of TLR3 in malignant cells. The gene discussed is TLR3; the disease is esophageal cancer.