To determine whether PRMT5 has biological functions similar to those of HSF1 in DLBCL, we established PRMT5-knockdown SU-DHL-2, SU-DHL-4, and SU-DHL-6 cells and verified the knockdown efficiency using qRT‒PCR (Fig. 7B). Here, PRMT5 is linked to diffuse large B-cell lymphoma.