SOD1 and amyotrophic lateral sclerosis: Analysis of the transcriptional dysregulation in vulnerable spinal MNs in SOD1-ALS mice (Perrin et al. 2005; Lobsiger et al. 2007; Sun et al. 2015; Shadrach et al. 2021) has revealed a response to DNA damage and cell injury as well as activation of compensatory regeneration.