Given that the oligomeric state is essential for PRMT1 to achieve stable binding to RGG-rich substrates and facilitate their methylation in vivo, we investigated whether perturbations in PRMT1 oligomerization, which we have observed to inhibit PDAC tumor growth, are closely linked to alterations in the functions of a subset of RBPs containing the RGG motif. Here, PRMT1 is linked to neoplasm.