ERBB2 and head and neck squamous cell carcinoma: They revealed that IL-12p70, a cytokine derived from adenovirus, promotes persistence of anti-HER2 CAR-T cells within the tumor site and eradication of disseminated HNSCC cells in vivo.91,92 A first-in-human phase 1 study of binary oncolytic adenovirus in combination with HER2-specific autologous CAR-T cells in patients with advanced HER2+ solid tumors is designed to investigate this treatment approach.