Regarding proteins with cis-pQTLs, our results indicate that MMP-9 and DC-SIGNare associated with an increased risk of spontaneous abortion(OR=1.11(1.03-1.19), p=0.0037; OR=1.09(1.02-1.16),p=0.00989, while HBAZ and NELL1 exhibit a protective effectagainst spontaneous abortion (OR=0.96(0.94-0.99), p=0.0052;OR=0.94(0.9- 0.98), p=0.00854. The gene discussed is HBZ; the disease is abortion.