MMP9 and DC-SIGN were associated with increased spontaneous abortion risk(OR=1.11(1.03-1.19), P=3.70x10-3; OR=1.09(1.02-1.16),p=9.89x10-3), while HBAZ and NELL1 hadprotective effects (OR=0.96(0.94- 0.99),p=5.20x10-3; OR=0.94(0.9-0.98),p=8.54x10-3). The gene discussed is HBZ; the disease is abortion.