41 infertile men were divided intoconsumed prebiotic (Flortec) and control (food starch). The semenparameters (volume, concentration, motility, and sperm morphology)and levels of follicle-stimulating hormone (FSH), luteinizinghormone (LH), and testosterone significantly improved after intakeof prebiotic. The gene discussed is PLOD1; the disease is Infertility.