Different species of Lactobacillus cover many of the body surfaces,including the oral cavity, the vaginal cavity, the male genitourinary tract, and thegastrointestinal tract; this genus is one of the most important representatives ofthe intestinal microbiota and has a substantial impact on reproduction and fertilitysince dysbiosis of the intestinal microbiota can increase the permeability of theblood-testis barrier and affect the serum levels of FSH, LH and testosterone (Cao et al., 2023)leading toincreased male infertility. Here, PLOD1 is linked to male infertility.