AXT was previously loaded into many Nano formulations for the treatment of cancer including nanohybrid liposomal nanoparticles [20], dual pH responsive micelle [21], PEGylated lipid bilayer supported mesoporous silica nanoparticles [12], pH-Activatable copper-axitinib coordinated multifunctional nanoparticles [22]. This evidence concerns the gene CNTN2 and cancer.