Additionally, in lung squamous cell carcinoma(LSCC), lung adenocarcinoma (LUAD), and head and neck squamous cellcarcinoma (HNSCC), the correlation change is statistically significant.Some genes also exhibit a decrease in the correlation in tumor tissues.SPTA1 has a negative Δ_corr in four of the tissue types we examined;only in ccRCC is the Δ_corr positive. The gene discussed is SPTA1; the disease is head and neck squamous cell carcinoma.