Characterization of the adult hearts through picrosirius red staining used for myocardial fibrosis detection showed no difference between the genotypes (Fig. S16A), even though the hearts of female KI mice showed a mild increase in the expression of Col1a1 and Ccn2 genes that are associated with fibrosis and tissue remodeling [72, 73] (Fig. S16B). Here, COL1A1 is linked to Myocardial fibrosis.