G0S2 and neoplasm: In the human dataset, DEG analysis between tumor‐derived and non‐malignant mural cells showed increased expression of collagen isoforms, fibronectin, G0S2, and immune‐related genes in tumor‐resident mural cells (Fig. 4C), which led to increased pathways such as endodermal cell differentiation, collagen synthesis and metabolism, bone and skeletal system morphogenesis, and granulocyte migration (Fig. 4C).