Next, to investigate the role of c-Kit signaling on IL-1β/IL-23–driven ILC3 activation and lung pathogenesis, we compared IL-1β/IL-23–induced neutrophilic inflammation, airway hyperreactivity (AHR), and ILC3 responses between c-Kit deficient (KitW-sh) mice and their WT counterparts. Here, KIT is linked to Irritability.