In adulthood, the reproductive phenotype observed in Kiss1- Mc4r KO and Mc4rloxTB female mice (increased LH, irregular estrous cycles, oligo-ovulation, increased cystic follicles) correlates with the phenotype observed in PCOS mouse models (Moore et al., 2013; McCarthy et al., 2022). Here, KISS1 is linked to polycystic ovary syndrome.