TNNT2 and myocarditis: The rationale for choosing hs-cTnT over troponin I is its higher sensitivity in detecting both cardiac [105] and skeletal muscle injury, which is relevant given the T cell–mediated cytotoxicity affecting both myocardium and skeletal muscle in ICI toxicity; however, clinicians should be aware that hs-cTnT may be elevated in isolated myositis, potentially leading to false positives in the absence of myocarditis [106].