This finding aligns with growing evidence that an immunosuppressive TME can support metastasis by enhancing tumor cell movement through the release of specific cytokines.[37, 38, 39, 40] Furthermore, capable of spreading more readily to lymph nodes can, in turn, recruit additional Tregs into the TME.[41] Taken together, these observations raise the question of whether the accumulation of GITR+ Tregs directly drives tumor metastasis or disease progression, warranting further investigation. This evidence concerns the gene TNFRSF18 and neoplasm.