TNFRSF18 and neoplasm: Other classification systems also show that active anti‐tumor immunity often appears alongside immunosuppressive features.[48, 49, 50] Specifically, Peter et al.'s classification of the PDAC TME, for example, identified an “Immunogenic” subtype characterized by the enrichment of both Tregs and CD8+ T cells, suggesting a complex interplay of immune activation and suppression.[51] Together, these findings imply that the presence of GITR− Tregs may reflect an actively engaged intratumoral immune response rather than an environment devoid of immune activity.[46]