However, tumor‐intrinsic PD‐1 was also found in tumor cells and exhibited its pro‐tumoral effect in various cancers, including PDAC.[9, 10, 34] As a previous study has detailed reported that tumor‐intrinsic PD‐1 could activate the MET signaling in PDAC cells to promote growth, migration, and invasion.[11] In this study, we elucidated that tumor‐intrinsic PD‐1 is clinically correlated with MET activation, thereby fostering an immunosuppressive TME, which occurs, in part, through the accumulation of GITR+ Tregs in PDAC. The gene discussed is TNFRSF18; the disease is cancer.